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— Tailored wellness

Sleep better

Restorative Rest as the Cornerstone of Well-being. What Science Understands Today about Sleep and the Endocannabinoid System.

— What science says

The Science of Sleep

01

The Endocannabinoid System and Sleep

Sleep is regulated by a complex orchestra of neurotransmitters—GABA, serotonin, adenosine, melatonin—and by circadian rhythms. The endocannabinoid system (ECS) is actively involved: it has CB1 receptors in key brain areas for the sleep-wake cycle, such as the hypothalamus and brainstem.

Murillo-Rodríguez et al. (2017). The Endocannabinoid System Modulating Levels of Consciousness, Emotions and Likely Dream Contents. CNS & Neurological Disorders.
02

What the research says

A retrospective study by Shannon et al. (2019), published in The Permanente Journal with 72 patients, found that 66.7% of participants with sleep problems reported improvement in subjective scores during the first month. It was an observational study without a placebo group; effects vary among individuals.

Shannon, S. et al. (2019). Cannabidiol in Anxiety and Sleep: A Large Case Series. The Permanente Journal, 23, 18-041.
03

How to use it in your routine

Sublingual oils are usually the preferred option: they are taken 30-60 min before bedtime so that absorption coincides with the time one starts to fall asleep. The most prudent rule: start with low doses (10-15 mg) and increase every 3-7 days. Combinations with melatonin, valerian, or passionflower are popular.

Babson, K. A. et al. (2017). Cannabis, Cannabinoids, and Sleep. Current Psychiatry Reports, 19(4).

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— Keep learning

Learn more about sleep and CBD

Evidence-based articles to understand how rest interacts with your endocannabinoid system.

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