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— Tailored wellness

Pain and Joints

What science is researching about CBD applied to chronic pain, joints, and inflammatory processes.

— What science says

The Science of Joint Pain

01

SEC in Joints and Pain

Joints, cartilage, and synovial tissues contain functional CB1 and CB2 receptors. CB2 receptors, in particular, are highly expressed in immune system cells that are activated during inflammatory joint processes. This explains why the endocannabinoid system is being investigated as a therapeutic target in rheumatic diseases and osteoarthritis.

La Porta, C. et al. (2014). Involvement of the endocannabinoid system in osteoarthritis pain. European Journal of Neuroscience, 39(3).
02

What the research says

A systematic review in Frontiers in Pharmacology (2020) gathered moderate evidence of neuropathic and joint pain modulation by cannabinoids. Specifically in osteoarthritis, several preclinical studies have shown effects on inflammation markers. In humans, the evidence is promising but still requires further large-scale clinical trials.

Argueta, D. A. et al. (2020). A Balanced Approach for Cannabidiol Use in Chronic Pain. Frontiers in Pharmacology, 11, 561.
03

How to use it in your routine

Topical formulations (balms, creams, roll-ons) are ideal for localized areas: they act on cutaneous and joint CB2 receptors without entering systemic circulation significantly. For general support, sublingual oils are more efficient. Typical concentrations: 500-1500 mg of CBD per topical container. It is common to combine local + systemic use.

Hammell, D. C. et al. (2016). Transdermal cannabidiol reduces inflammation and pain-related behaviors. European Journal of Pain, 20(6).

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— Keep learning

Pain, joints, and CBD

Readings on the endocannabinoid system applied to chronic and joint pain.

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